منابع مشابه
PCSK9 Inhibitors: What Lies Beyond Monoclonal Antibodies?
2015 has been an exciting year for cardiovascular research. Consecutive US FDA approvals of alirocumab in July and evolocumab in August meant that they were in the spotlight at the European Society of Cardiology and American Heart Association congresses—two of the largest annual meetings of cardiologists in the world. Thesemonoclonal antibodies (mAbs) bind to and inhibit the enzyme proprotein c...
متن کاملMonoclonal Antibodies
SUMMARY Monoclonal Antibodies are identical antibodies and Can be generated in ultimated amounts by countinuos cultures of single antibody- secreting cells. These cell lines are produced by cell fusion of normal lymphocytes to cells of a myeloma tumor cell line, which confers on the antibody producing hybrid cell, immortality and the ability grow as atumor in animals. monoclonal antibodies c...
متن کاملPCSK9 Inhibition With Monoclonal Antibodies: Modern Management of Hypercholesterolemia
Current guidelines for hypercholesterolemia treatment emphasize lifestyle modification and lipid-modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary class of agents used for the treatment of hypercholesterolemia. Although statins are effective for many patients, they fail to achieve optimal reduction in lipids for some patients, including those who have or a...
متن کاملPCSK9 inhibitors: monoclonal antibodies for the treatment of hypercholesterolemia.
In 2015 the U.S. Food and Drug Administration approved the first two proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, alirocumab (Praluent®; Sanofi/ Regeneron) and evolocumab (Repatha®; Amgen), for use in patients with heterozygous and homozygous familial hypercholesterolemia and for patients intolerant of statins or those with a major risk of cardiovascular disease (CVD) but u...
متن کاملMonoclonal antibodies: an introduction.
Monoclonal antibodies (Mca) are aNTibodies ThaT are identical and derived from one type of immune cell, each a clone of a single parent cell. The extraordinarily specific nature of these antibodies is what makes MCA unique and opens up the possibilities of revolutionary applications including targeted therapy and other diagnostic applications (such as pregnancy test and testing for acquired imm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heart Views
سال: 2020
ISSN: 1995-705X
DOI: 10.4103/heartviews.heartviews_20_20